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Journal of Cognitive Neuroscience

June 2013, Vol. 25, No. 6, Pages 887-902
(doi: 10.1162/jocn_a_00341)
© 2013 Massachusetts Institute of Technology
Frontoparietal Traffic Signals: A Fast Optical Imaging Study of Preparatory Dynamics in Response Mode Switching
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Coordination between networks of brain regions is important for optimal cognitive performance, especially in attention demanding tasks. With the event-related optical signal (a measure of changes in optical scattering because of neuronal activity) we can characterize rapidly evolving network processes by examining the millisecond-scale temporal correlation of activity in distinct regions during the preparatory period of a response mode switching task. Participants received a precue indicating whether to respond vocally or manually. They then saw or heard the letter “L” or “R,” indicating a “left” or “right” response to be implemented with the appropriate response modality. We employed lagged cross-correlations to characterize the dynamic connectivity of preparatory processes. Our results confirmed coupling of frontal and parietal cortices and the trial-dependent relationship of the right frontal cortex with response preparation areas. The frontal-to-modality-specific cortex cross-correlations revealed a pattern in which first irrelevant regions were deactivated, and then relevant regions were activated. These results provide a window into the subsecond scale network interactions that flexibly tune to task demands.