Monthly
288 pp. per issue
6 x 9, illustrated
ISSN
0899-7667
E-ISSN
1530-888X
2014 Impact factor:
2.21

Neural Computation

February 2007, Vol. 19, No. 2, Pages 303-326
(doi: 10.1162/neco.2007.19.2.303)
© 2007 Massachusetts Institute of Technology
The Astrocyte as a Gatekeeper of Synaptic Information Transfer
Article PDF (457.11 KB)
Abstract

We present a simple biophysical model for the coupling between synaptic transmission and the local calcium concentration on an enveloping astrocytic domain. This interaction enables the astrocyte to modulate the information flow from presynaptic to postsynaptic cells in a manner dependent on previous activity at this and other nearby synapses. Our model suggests a novel, testable hypothesis for the spike timing statistics measured for rapidly firing cells in culture experiments.