Fatigue as a Window to the Brain

Edited by John DeLuca
Foreword by Simon Wessely

Although fatigue has been actively investigated for more than 100 years, we have progressed little in either its theoretical or practical understanding. Fatigue has been considered to be both a symptom and an illness. Fatigue is a primary reason for patient visits to the physician's office, but it is difficult to measure and offers doctors little important information for diagnosis. Fatigue as a Window to the Brain gathers experts on a wide variety of disorders to consider what the presence of fatigue tells us about how the brain works—more specifically, to identify the neural mechanisms potentially responsible for fatigue. The book looks at many of the major conditions in which fatigue is observed, with the hope that patterns may emerge that will suggest paths for future research. It will be of interest to neuroscientists, clinical researchers, and physicians and other clinicians.

After discussing the nature of fatigue—its history and epidemiology and its assessment, measurement, and interpretation—the book turns to specific conditions associated with fatigue. It considers neurological conditions, including multiple sclerosis and stroke; psychiatric conditions as well as the overall treatment of fatigue in psychiatry; and general medical conditions, including HIV, heart disease, lupus, cancer, and others. The book then offers an overview of treatment approaches. It concludes with a definition of fatigue—both "primary" and "secondary"—and suggestions for future study.

Table of Contents

  1. Foreword by Simon Wessely
  2. Preface
  3. The Nature of Fatigue
  4. 1. What Is Fatigue? History and Epidemiology

    Susan Torres-Harding and Leonard A. Jason

  5. 2. The Assessment and Measurement of Fatigue

    Christopher Christodoulou

  6. 3. Fatigue, Cognition, and Mental Effort

    John DeLuca

  7. Fatigue in Neurological Conditions
  8. 4. Multiple Sclerosis and Fatigue

    Lauren B. Krupp, Christopher Christodoulou, and Harold Schombert

  9. 5. Fatigue after Stroke

    Maja Stulemeijer, Luciano Fasotti, and Gijs Bleijenberg

  10. 6. Fatigue after Traumatic Brain Injury

    Elie P. Elovic, Nino M. Dobrovic, and Jonathan L. Fellus

  11. 7. Fatigue in Other Neurological Conditions

    Jonathan L. Fellus and Wahid Rashidzada

  12. Fatigue in Psychiatric Conditions
  13. 8. The Diagnosis and Treatment of Fatigue in Psychiatry: A Historical Overview

    Edward Shorter

  14. 9. Chronic Fatigue Syndrome and the Brain

    Susan K. Johnson and John DeLuca

  15. 10. Depression and Fatigue

    Susan K. Johnson

  16. 11. Fatigue and Somatization

    Lesley A. Allen and Javier I. Escobar

  17. Fatigue in General Medical and Other Conditions
  18. 12. HIV-Related Fatigue

    Natasha Dufour, Benoit Dub, and William Breitbart

  19. 13. Fatigue and Sleep

    Stephen P. Duntley

  20. 14. Heart Disease, Cardiovascular Functioning, and Fatigue

    Scott Siegel and Neil Schneiderman

  21. 15. Fatigue in Systemic Lupus Erythematosus and Related Autoimmune Disorders

    Elizabeth Kozora

  22. 16. Cancer and Fatigue: Insights from Studies of Women Treated for Breast Cancer

    Paul B. Jacobsen and Kristine A. Donovan

  23. 17. Psychoneuroimmunology and Fatigue

    Nancy G. Klimas, Mary Ann Fletcher, Kevin Maher, and Rasha Lawrence

  24. Treatment of Fatigue
  25. 18. Rehabilitation and Treatment of Fatigue

    Gudrun Lange, Dane B. Cook, and Benjamin H. Natelson

  26. Conclusions
  27. 19. Fatigue: Its Definition, Its Study, and Its Future

    John DeLuca

  28. Contributors
  29. Index